3. rejected—"forsaken of men" [Gesenius]. "Most abject of men." Literally, "He who ceases from men," that is, is no longer regarded as a man [Hengstenberg]. (See on Isa 52:14; Isa 49:7).
man of sorrows—that is, whose distinguishing characteristic was sorrows.
acquainted with—familiar by constant contact with.
grief—literally, "disease"; figuratively for all kinds of calamity (Jer 6:14); leprosy especially represented this, being a direct judgment from God. It is remarkable Jesus is not mentioned as having ever suffered under sickness.
and we hid … faces—rather, as one who causes men to hide their faces from Him (in aversion) [Maurer]. Or, "He was as an hiding of the face before it," that is, as a thing before which a man covers his face in disgust [Hengstenberg]. Or, "as one before whom is the covering of the face"; before whom one covers the face in disgust [Gesenius].
we—the prophet identifying himself with the Jews. See Horsley's view (see on Isa 53:1).
esteemed … not—negative contempt; the previous words express positive.