3. God loathes even the sacrifices of the wicked (Isa 1:11; Pr 15:8; 28:9).
is as if—Lowth not so well omits these words: "He that killeth an ox (presently after) murders a man" (as in Eze 23:39). But the omission in the Hebrew of "is as if"—increases the force of the comparison. Human victims were often offered by the heathen.
dog's neck—an abomination according to the Jewish law (De 23:18); perhaps made so, because dogs were venerated in Egypt. He does not honor this abomination by using the word "sacrifice," but uses the degrading term, "cut off a dog's neck" (Ex 13:13; 34:20). Dogs as unclean are associated with swine (Mt 7:6; 2Pe 2:22).
oblation—unbloody: in antithesis to "swine's blood" (Isa 65:4).
burneth—Hebrew, "he who offereth as a memorial oblation" (Le 2:2).
they have chosen—opposed to the two first clauses of Isa 66:4: "as they have chosen their own ways, &c., so I will choose their delusions.