21. regard—literally, "turn thyself to."
iniquity—namely, presumptuous speaking against God (Job 34:5, and above, see on Job 36:17, 18).
rather than—to bear "affliction" with pious patience. Men think it an alleviation to complain against God, but this is adding sin to sorrow; it is sin, not sorrow, which can really hurt us (contrast Heb 11:25).