4. (Isa 65:11).
estranged this place—devoted it to the worship of strange gods: alienating a portion of the sacred city from God, the rightful Lord of the temple, city, and whole land.
nor their fathers—namely, the godly among them; their ungodly fathers God makes no account of.
blood of innocents—slain in honor of Molech (Jer 7:31; Ps 106:37).